Rapid strategy for screening by pyrosequencing of influenza virus reassortants--candidates for live attenuated vaccines.
Identifieur interne : 000682 ( Main/Exploration ); précédent : 000681; suivant : 000683Rapid strategy for screening by pyrosequencing of influenza virus reassortants--candidates for live attenuated vaccines.
Auteurs : Svetlana V. Shcherbik [États-Unis] ; Nicholas C. Pearce [États-Unis] ; Marnie L. Levine [États-Unis] ; Alexander I. Klimov [États-Unis] ; Julie M. Villanueva [États-Unis] ; Tatiana L. Bousse [États-Unis]Source :
- PloS one [ 1932-6203 ] ; 2014.
Descripteurs français
- KwdFr :
- Humains, Sous-type H3N2 du virus de la grippe A (génétique), Sous-type H3N2 du virus de la grippe A (immunologie), Séquençage nucléotidique à haut débit, Vaccins antigrippaux (génétique), Vaccins antigrippaux (immunologie), Vaccins atténués (immunologie), Virus recombinants (génétique), Virus recombinants (immunologie).
- MESH :
English descriptors
- KwdEn :
- High-Throughput Nucleotide Sequencing, Humans, Influenza A Virus, H3N2 Subtype (genetics), Influenza A Virus, H3N2 Subtype (immunology), Influenza Vaccines (genetics), Influenza Vaccines (immunology), Reassortant Viruses (genetics), Reassortant Viruses (immunology), Vaccines, Attenuated (immunology).
- MESH :
- chemical , genetics : Influenza Vaccines.
- genetics : Influenza A Virus, H3N2 Subtype, Reassortant Viruses.
- immunology : Influenza A Virus, H3N2 Subtype, Influenza Vaccines, Reassortant Viruses, Vaccines, Attenuated.
- High-Throughput Nucleotide Sequencing, Humans.
Abstract
Live attenuated influenza vaccine viruses (LAIVs) can be generated by classical reassortment of gene segments between a cold adapted, temperature sensitive and attenuated Master Donor Virus (MDV) and a seasonal wild-type (wt) virus. The vaccine candidates contain hemagglutinin (HA) and neuraminidase (NA) genes derived from the circulating wt viruses and the remaining six genes derived from the MDV strains. Rapid, efficient selection of the viruses with 6∶2 genome compositions from the large number of genetically different viruses generated during reassortment is essential for the biannual production schedule of vaccine viruses.
DOI: 10.1371/journal.pone.0092580
PubMed: 24647786
Affiliations:
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Le document en format XML
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The vaccine candidates contain hemagglutinin (HA) and neuraminidase (NA) genes derived from the circulating wt viruses and the remaining six genes derived from the MDV strains. Rapid, efficient selection of the viruses with 6∶2 genome compositions from the large number of genetically different viruses generated during reassortment is essential for the biannual production schedule of vaccine viruses.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li></region></list><tree><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Shcherbik, Svetlana V" sort="Shcherbik, Svetlana V" uniqKey="Shcherbik S" first="Svetlana V" last="Shcherbik">Svetlana V. Shcherbik</name></region><name sortKey="Bousse, Tatiana L" sort="Bousse, Tatiana L" uniqKey="Bousse T" first="Tatiana L" last="Bousse">Tatiana L. Bousse</name><name sortKey="Klimov, Alexander I" sort="Klimov, Alexander I" uniqKey="Klimov A" first="Alexander I" last="Klimov">Alexander I. Klimov</name><name sortKey="Levine, Marnie L" sort="Levine, Marnie L" uniqKey="Levine M" first="Marnie L" last="Levine">Marnie L. Levine</name><name sortKey="Pearce, Nicholas C" sort="Pearce, Nicholas C" uniqKey="Pearce N" first="Nicholas C" last="Pearce">Nicholas C. Pearce</name><name sortKey="Villanueva, Julie M" sort="Villanueva, Julie M" uniqKey="Villanueva J" first="Julie M" last="Villanueva">Julie M. Villanueva</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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